Gonadotroph-Specific Expression of Metallothionein Fusion Genes in Pituitaries of Transgenic Mice
- 28 February 1986
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 231 (4741), 1002-1004
- https://doi.org/10.1126/science.2868526
Abstract
Transgenic mice expressing a metallothionein-somatostatin fusion gene contain high concentrations of somatostatin in the anterior pituitary gland, a tissue that does not normally produce somatostatin. Immunoreactive somatostatin within the anterior pituitaries was found exclusively within gonadotrophs. Similarly, a metallothionein-human growth-hormone fusion gene was also expressed selectively in gonadotrophs. It is proposed that sequences common to the two fusion genes are responsible for the gonadotroph-specific expression.Keywords
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