Homology Modeling of GPCRs
- 14 April 2009
- book chapter
- Published by Springer Science and Business Media LLC
- Vol. 552, 97-113
- https://doi.org/10.1007/978-1-60327-317-6_7
Abstract
Over 1000 sequences likely to encode G protein-coupled receptors (GPCRs) are currently available in publicly accessible and proprietary databases and this number may grow with the refinement of a number of different genomes. However, despite recent efforts in the crystallization of these proteins, homology modeling approaches are becoming widely used as a method for obtaining quantitative and qualitative information for structure-based drug design as well as the interpretation of experimental data.Keywords
This publication has 39 references indexed in Scilit:
- A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic ReceptorStructure, 2008
- Crystal Structure of a Thermally Stable Rhodopsin MutantJournal of Molecular Biology, 2007
- Structures of the extracellular regions of the group II/III metabotropic glutamate receptorsProceedings of the National Academy of Sciences of the United States of America, 2007
- Crystal structure of a photoactivated deprotonated intermediate of rhodopsinProceedings of the National Academy of Sciences of the United States of America, 2006
- Local peptide movement in the photoreaction intermediate of rhodopsinProceedings of the National Academy of Sciences of the United States of America, 2006
- Crystallographic Analysis of Primary Visual PhotochemistryAngewandte Chemie-International Edition, 2006
- T-coffee: a novel method for fast and accurate multiple sequence alignment 1 1Edited by J. ThorntonJournal of Molecular Biology, 2000
- SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modelingElectrophoresis, 1997
- AQUA and PROCHECK-NMR: Programs for checking the quality of protein structures solved by NMRJournal of Biomolecular NMR, 1996
- Comparative Protein Modelling by Satisfaction of Spatial RestraintsJournal of Molecular Biology, 1993