Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis
Open Access
- 7 April 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (12), 2564-2568
- https://doi.org/10.1016/j.febslet.2005.03.070
Abstract
Immunization against the Aβ peptide reverses the pathologic and behavioral manifestations of Alzheimer's disease in murine models. Since active immunization is associated with an autoimmune meningoencephalitis in a subset of humans, passive transfer of anti‐Aβ immunoglobulin is being pursued as a potentially safer alternative. We have identified cases of meningoencephalitis subsequent to peripheral and intracerebral passive immunization of Tg2576 mice. The vasocentric mononuclear infiltrate localized only to brain regions affected by Aβ amyloid deposits suggesting that the inflammatory reaction was Aβ specific. This report indicates that current passive immunization in humans should proceed with careful regard for autoimmune complications.This publication has 13 references indexed in Scilit:
- Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case reportNature Medicine, 2003
- Cerebral Hemorrhage After Passive Anti-Aβ ImmunotherapyScience, 2002
- Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's diseaseProceedings of the National Academy of Sciences of the United States of America, 2001
- Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's diseaseNature, 2000
- Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's diseaseNature, 2000
- Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer diseaseNature Medicine, 2000
- Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouseNature, 1999
- Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic MiceScience, 1996
- Distribution of tau proteins in the normal human central and peripheral nervous system.Journal of Histochemistry & Cytochemistry, 1989
- Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid proteinBiochemical and Biophysical Research Communications, 1984