High Plasma Levels of 8-Methoxypsoralen following Bath Water Delivery in Dermatological Patients
- 14 August 2003
- journal article
- clinical trial
- Published by S. Karger AG in Skin Pharmacology and Physiology
- Vol. 16 (5), 305-312
- https://doi.org/10.1159/000072070
Abstract
With respect to the clinical advantages known for bath PUVA therapy, it was of interest to compare the plasma levels of 8-methoxypsoralen (8-MOP) in bath therapy with those after oral administration for a better insight into the pharmacokinetics of 8-MOP following different modes of application. Considerable high plasma levels of 8-MOP were observed after bath therapy with interindividual variability. The half-life of plasma 8-MOP was markedly shorter after bath PUVA than after oral application. The pharmacokinetic profile of 8-MOP differs according to the mode of application.Keywords
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