Acetylenic Acids from the Aerial Parts of Nanodea muscosa
- 1 May 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 66 (5), 722-724
- https://doi.org/10.1021/np020513e
Abstract
The aerial parts of Nanodea muscosa, collected in Chile, yielded two new acetylenic acids. Their structures were elucidated by spectroscopic analyses, including 2D NMR techniques, as (13E)-octadec-13-en-11-ynoic acid (1) and (2E)-octadec-2-en-4-ynedioic acid (2). Compound 2 constitutes the first example of a conjugated ene-yne fatty diacid isolated from a natural source. Compounds 1 and 2 did not exhibit toxicity toward a panel of DNA damage checkpoint defective yeast mutants or show affinity for the 5-HT(1A), 5-HT(2A), D(2), and H(1) receptors.Keywords
This publication has 16 references indexed in Scilit:
- Chemosensitization of a Multidrug-Resistant Leishmania tropica Line by New Sesquiterpenes from Maytenus magellanica and Maytenus chubutensisJournal of Medicinal Chemistry, 2001
- Biosynthesis and Degradation of Fatty AcidsPublished by Elsevier BV ,1999
- Bisabolane sesquiterpenoids from Santalum austrocaledonicumPhytochemistry, 1997
- New 2-Piperazinylbenzimidazole Derivatives as 5-HT3 Antagonists. Synthesis and Pharmacological EvaluationJournal of Medicinal Chemistry, 1997
- Bee ProductsPublished by Springer Science and Business Media LLC ,1997
- Alkaloids and Coumarins of Casimiroa edulisJournal of Natural Products, 1985
- New synthesis of 1-triacontanolTetrahedron Letters, 1984
- Chlorophyll B. Totalzuordnung des 13C-NMR-spektrumsTetrahedron Letters, 1983
- Olaxoside, a saponin from Olax andronensis, Olax glabriflora and Olax psittacorumPhytochemistry, 1981
- The 220 MHz NMR spectra of phytosterolsPhytochemistry, 1976