Pain-related electrical potentials of the human nasal mucosa elicited by chemical stimulation
- 1 June 1985
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Pain
- Vol. 22 (2), 151-163
- https://doi.org/10.1016/0304-3959(85)90175-7
Abstract
For the first time a non-invasive method was employed to record pain-related electrical potentials from the human respiratory nasal mucosa. Gaseous stimulants at painful concentrations were presented by the newly developed stimulating device. The amplitudes of the potentials were found correlated (a) with concentrations of the stimulants, and (b) with subjective estimations of pain intensity. The local anesthetic tetracaine hydrochloride, and also a systemically administered analgesic drug pentazocine given prior to painful stimulation decreased the amplitude of the negative potentials. The peripheral response was interpreted as a summated receptor potential from chemical nociceptors. It is thought to be analogous to the electro-olfactogram. This non-invasive technique of stimulation and recording offers an objective and quantitative measure related to pain sensations and their inhibition by analgesic drugs.Keywords
This publication has 8 references indexed in Scilit:
- Temporal integration of pungencyChemical Senses, 1984
- Principal component analysis of pain-related cerebral potentials to mechanical and electrical stimulation in manElectroencephalography and Clinical Neurophysiology, 1982
- Latencies of chemically evoked discharges in human cutaneous nociceptors and of the concurrent subjective sensationsNeuroscience Letters, 1980
- Single trial analysis of evoked potentials to noxious thermal stimulation in manPain, 1980
- III - Prostaglandin hyperalgesia: Relevance of the peripheral effect for the analgesic action of opioid-antagonistsProstaglandins, 1979
- A comparison between the discharges of human nociceptive nerve fibres and the subject's ratings of his sensations.The Journal of Physiology, 1979
- Evoked cerebral responses to noxious thermal stimuli in humansExperimental Brain Research, 1976
- Cerebral responses to electrical tooth pulp stimulation in manNeurology, 1975