Effect of Atrial Natriuretic Peptide on Electrical Defibrillation Efficacy
- 1 September 1998
- journal article
- research article
- Published by Wiley in Journal of Cardiovascular Electrophysiology
- Vol. 9 (9), 962-969
- https://doi.org/10.1111/j.1540-8167.1998.tb00136.x
Abstract
In vitro studies have suggested that human atrial natriuretic peptide (ANP) modulates the electrophysiologic properties of myocardial cells. This study assessed whether ANP could influence defibrillation efficacy. In 35 anesthetized dogs, the transcardiac defibrillation threshold (DFT) as well as hemodynamic and electrophysiologic variables were determined before and during treatment with ANP (n = 11), hydralazine (n = 11), or saline (n = 13). ANP (1.5 microg/kg + 0.2 microg/kg per min) increased the plasma concentration of cyclic GMP (a second messenger for ANP) and significantly decreased aortic blood pressure (mean 100+/-11 mmHg to 83+/-15 mmHg). ANP also prolonged ventricular repolarization (effective refractory period 157+/-7 msec to 165+/-11 msec) and markedly reduced DFT (5.4+/-1.2 J to 3.8+/-0.7 J [P < 0.01]) without changing pulmonary artery pressure or sinus cycle length. Neither saline nor hydralazine (1.5 mg/kg) had a significant effect on DFT (saline 4.7+/-2.1 J to 4.6+/-2.4 J; hydralazine 4.3+/-2.0 J to 4.2+/-1.9 J), although hydralazine caused pronounced hypotension (mean aortic pressure 103+/-9 mmHg to 74+/-13 mmHg). These results suggest that ANP increases defibrillation efficacy, and that this effect is not necessarily shared by other vasodilating agents.Keywords
This publication has 40 references indexed in Scilit:
- Can a Class III Antiarrhythmic Drug Improve Electrical Defibrillation Efficacy During Ventricular Fibrillation?Journal of the American College of Cardiology, 1997
- Efficacy of prolonged infusion of urodilatin [ANP-(95-126)] in patients with congestive heart failureAmerican Heart Journal, 1995
- Metabolic Determinants of DefibrillationCirculation, 1995
- Oral clofilium produces sustained lowering of defibrillation energy requirements in a canine model.Circulation, 1991
- Hemodynamic and hormone changes during induced ventricular tachycardia secondary to coronary artery diseaseThe American Journal of Cardiology, 1989
- Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function.Circulation, 1987
- Effects of encainide and its metabolites on energy requirements for defibrillation.Circulation, 1986
- Atrial Natriuretic Peptide Elevation in Congestive Heart Failure in the HumanScience, 1986
- Adrenergically mediated variations in the energy required to defibrillate the heart: observations in closed-chest, nonanesthetized dogs.Circulation, 1986
- PLASMA ATRIAL NATRIURETIC FACTOR IN CONGESTIVE HEART FAILUREThe Lancet, 1986