Development of the cortical dysplasia of type II lissencephaly
- 1 June 1993
- journal article
- Published by Wiley in Neuropathology and Applied Neurobiology
- Vol. 19 (3), 209-213
- https://doi.org/10.1111/j.1365-2990.1993.tb00430.x
Abstract
A detailed neuropathological study of five immature brains with type II lissencephaly is reported. The cases described include two pairs of siblings. One infant survived for 2 months after birth, the others died at 18, 20, 20 and 32 weeks of gestation. This series of cases demonstrates the sequence in which the malformation develops from mid-gestation to post-natal life and shows that type II lissencephaly is not an intracortical malformation but is the result of massive glial and neuronal ectopia in the leptomeninges. This results from a failure of arrest of neuronal migration due to defects in the integrity of the pial/glial barrier.Keywords
This publication has 16 references indexed in Scilit:
- Destruction of meningeal cells over the medial cerebral hemisphere of newborn hamsters prevents the formation of the infrapyramidal blade of the dentate gyrusJournal of Comparative Neurology, 1992
- Muscle‐eye‐brain disease and Walker‐Warburg syndromeAmerican Journal of Medical Genetics, 1990
- Understanding the molecules of neural cell contacts: emerging patterns of structure and functionTrends in Neurosciences, 1989
- Diagnostic criteria for Walker‐Warburg syndromeAmerican Journal of Medical Genetics, 1989
- Specification of Cerebral Cortical AreasScience, 1988
- Autosomal recessive eye and brain anomalies: Warburg syndromeThe Journal of Pediatrics, 1983
- Lissencephaly: two distinct clinico-pathological typesBrain & Development, 1983
- LISSENCEPHALYArchives of Neurology & Psychiatry, 1942