Clinical and radiologic evolution of synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: A single center study of a cohort of 71 subjects
Open Access
- 28 May 2009
- journal article
- sapho syndrome
- Published by Wiley in Arthritis Care & Research
- Vol. 61 (6), 813-821
- https://doi.org/10.1002/art.24540
Abstract
Objective To assess the basic features and outcomes of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. Methods We identified all patients seen in our unit between 1990 and 2008 diagnosed according to the proposed inclusion criteria with SAPHO syndrome, who had a followup of at least 2 years. Results Seventy-one patients (48 women, 23 men) with SAPHO syndrome were identified. The median disease duration at the end of followup was 10 years (interquartile range [IQR] 7–15 years), and the median followup duration was 11 years (IQR 6–11.5 years). Six patients were diagnosed with Crohn's disease. Fourteen patients had never had cutaneous involvement, but 8 patients presented >1 skin manifestation. Nine patients (13%) presented a limited (6 months. A total of 4% of the patients were HLA–B27 positive. Female sex (odds ratio [OR] 7.2, 95% confidence interval [95% CI] 2.2–22.9) and the presence at onset of anterior chest wall (ACW) involvement (OR 5.7, 95% CI 1.8–18.1), peripheral synovitis (P = 0.0036), skin involvement (OR 10.3, 95% CI 3.4–31.1), and high values of acute-phase reactants (OR 7.7, 95% CI 2.7–22) were correlated with a chronic disease course and involvement of new osteoarticular sites. Conclusion A chronic course is the more common evolution of SAPHO syndrome. Female sex, elevated erythrocyte sedimentation rate and C-reactive protein values, ACW involvement, peripheral synovitis, and skin involvement at the onset seem to be associated with a chronic course.Keywords
This publication has 39 references indexed in Scilit:
- Neutrophil dysfunction in a family with a SAPHO syndrome–like phenotypeArthritis & Rheumatism, 2008
- Clinical outcome in children with chronic recurrent multifocal osteomyelitisRheumatology, 2008
- Classification of Non-Bacterial Osteitis: Retrospective study of clinical, immunological and genetic aspects in 89 patientsRheumatology, 2007
- Conundrums in nosology: Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome and spondylarthritisArthritis Care & Research, 2006
- A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitisBone, 2006
- In SAPHO syndrome anti-TNF-α therapy may induce persistent amelioration of osteoarticular complaints, but may exacerbate cutaneous manifestationsRheumatology, 2006
- Diagnostic points and possible origin of osteomyelitis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome: a radiographic study of 77 mandibular osteomyelitis casesRheumatology, 2003
- Sustained response to tumor necrosis factor α–blocking agents in two patients with SAPHO syndromeArthritis & Rheumatism, 2002
- Evolution of chronic recurrent multifocal osteitis toward spondylarthropathy over the long termArthritis & Rheumatism, 2000
- Skeletal Disease, Arthro-osteitis, in Adult Patients with Pustulosis PalmoplantarisScandinavian Journal of Rheumatology, 1988