A Reduced SNARE Model for Membrane Fusion
- 10 March 2009
- journal article
- research article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 48 (13), 2330-2333
- https://doi.org/10.1002/anie.200804493
Abstract
Let's get together: A minimal model system was developed to mimic the SNARE-protein-mediated fusion of biological membranes (see picture). Fusion between two populations of liposomes is controlled by a pair of complementary lipidated oligopeptides that form noncovalent coiled-coil complexes and thereby force the membranes into close proximity to promote fusion. The model system displays the key characteristics of in vivo fusion events.Keywords
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