Using Serial Registered Brain Magnetic Resonance Imaging to Measure Disease Progression in Alzheimer Disease
Open Access
- 1 March 2000
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 57 (3), 339-344
- https://doi.org/10.1001/archneur.57.3.339
Abstract
ALZHEIMER DISEASE (AD) is characterized by gradual cognitive decline and progressive cerebral atrophy. At autopsy, the histopathological disease hallmarks of amyloid plaques and neurofibrillary tangles are accompanied by widespread synaptic and neuronal loss. Atrophy is a macroscopic consequence of these cellular losses that can be visualized in life using computed tomography or magnetic resonance imaging (MRI).1This publication has 9 references indexed in Scilit:
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