Histologic changes in the guinea pig gastrointestinal tract following 1 weeks' administration of chlorpromazine, haloperidol or atropine
- 1 July 1988
- journal article
- Published by Springer Science and Business Media LLC in Psychopharmacology
- Vol. 95 (3), 351-355
- https://doi.org/10.1007/bf00181946
Abstract
A comparison was made between the toxic effects of chronic chlorpromazine, haloperidol or atropine on the guinea pig intestinal tract. Chlorpromazine, administered at a dose of 30 mg/kg/day, IP for 7 days, produced marked pathologic changes in the guinea pig cecum, consisting of inflammation, edema and hemorrhage. None of these effects were noted when haloperidol, 2 or 10 mg/kg/day or atropine 30 mg/kg/day were similarly administered. Similar toxic effects may occur in humans on long-term chlorpromazine or other phenothiazine therapy, thereby accounting for the paralytic ileus observed with these drugs.This publication has 21 references indexed in Scilit:
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