Higher Post‐absorptive Skeletal Muscle LPL Activity in African American vs. Non‐Hispanic White Pre‐menopausal Women
Open Access
- 1 January 2008
- Vol. 16 (1), 199-201
- https://doi.org/10.1038/oby.2007.11
Abstract
Objective: Higher post‐absorptive post‐heparin plasma lipoprotein lipase (LPL) activity has been reported in African Americans as compared to non‐Hispanic whites but differences in tissue‐specific LPL activity are unclear. Methods and Procedures: Post‐absorptive skeletal muscle (SM)‐LPL (vastus lateralis) and subcutaneous abdominal adipose tissue (AT)‐LPL activity was measured in overweight, sedentary African American females (n = 11) as well as in their non‐Hispanic white counterparts (n = 6) during a period of controlled low fat (30%) diet (for 10 days) combined with physical activity (for days 8–10). Post‐absorptive substrate utilization was measured on day 10; fasting blood levels and SM and AT biopsies were obtained on day 11. Results: African Americans had significantly greater post‐absorptive SM‐LPL activity (P = 0.04) when compared to non‐Hispanic whites. There were no significant differences in post‐absorptive AT‐LPL activity, free fatty acids, and systemic fat oxidation or respiratory quotient between African American and white non‐Hispanic women in this study (P > 0.2 for all). Discussion: During a controlled low fat (30%) diet post‐absorptive vastus lateralis SM‐LPL activity is higher in sedentary pre‐menopausal African American as compared to non‐Hispanic white women.This publication has 15 references indexed in Scilit:
- Metabolic Inflexibility in Substrate Use Is Present in African-American But Not Caucasian Healthy, Premenopausal, Nondiabetic WomenJournal of Clinical Endocrinology & Metabolism, 2006
- Ethnic differences in postprandial triglyceride response to a fatty meal and lipoprotein lipase in lean and obese African American and Caucasian womenMetabolism, 2002
- Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men: Results from the HERITAGE Family StudyAtherosclerosis, 2001
- Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistanceProceedings of the National Academy of Sciences of the United States of America, 2001
- Overexpressing Human Lipoprotein Lipase in Mouse Skeletal Muscle Is Associated With Insulin ResistanceDiabetes, 2001
- Race, Visceral Adipose Tissue, Plasma Lipids, and Lipoprotein Lipase Activity in Men and WomenArteriosclerosis, Thrombosis, and Vascular Biology, 2000
- Visceral Fat and Race-Dependent Health Risks in Obese Nondiabetic Premenopausal WomenDiabetes, 1997
- Relationship between skeletal muscle lipoprotein lipase activity and 24-hour macronutrient oxidation.JCI Insight, 1993
- Lipoprotein LipaseThe New England Journal of Medicine, 1989
- Fat distribution and adipose tissue metabolism in non-obese male black African and Caucasian subjects.1986