Interleukin 7 (IL-7) selectively promotes mouse and human IL-17–producing γδ cells
Open Access
- 9 October 2012
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 109 (43), 17549-17554
- https://doi.org/10.1073/pnas.1204327109
Abstract
IL-17–producing CD27− γδ cells (γδ27− cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity. However, factors that promote them over IFN-γ–producing γδ27+ cells are poorly elucidated. Moreover, although human IL-17–producing γδ cells are commonly implicated in inflammation, such cells themselves have proved difficult to isolate and characterize. Here, murine γδ27− T cells and thymocytes are shown to be rapidly and substantially expanded by IL-7 in vitro and in vivo. This selectivity owes in substantial part to the capacity of IL-7 to activate STAT3 in such cells. Additionally, IL-7 promotes strong responses of IL-17–producing γδ cells to TCR agonists, thus reemphasizing the cells’ adaptive and innate potentials. Moreover, human IL-17–producing γδ cells are also substantially expanded by IL-7 plus TCR agonists. Hence, IL-7 has a conserved potential to preferentially regulate IL-17–producing γδ cells, with both biological and clinical implications.Keywords
This publication has 51 references indexed in Scilit:
- Rorγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in miceJCI Insight, 2012
- Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin InflammationImmunity, 2011
- Identification of a Novel Proinflammatory Human Skin-Homing Vγ9Vδ2 T Cell Subset with a Potential Role in PsoriasisThe Journal of Immunology, 2011
- Notch-Hes1 pathway is required for the development of IL-17–producing γδ T cellsBlood, 2011
- Regulation and function of IL-17A- and IL-22-producing γδ T cellsCellular and Molecular Life Sciences, 2011
- Chronic Mucocutaneous Candidiasis in Humans with Inborn Errors of Interleukin-17 ImmunityScience, 2011
- Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5Nature Immunology, 2011
- Fate mapping of IL-17-producing T cells in inflammatory responsesNature Immunology, 2011
- IL-17 and Th17 CellsAnnual Review of Immunology, 2009
- Thymic Selection Determines γδ T Cell Effector Fate: Antigen-Naive Cells Make Interleukin-17 and Antigen-Experienced Cells Make Interferon γImmunity, 2008