Relationship between Delusions and Regional Cerebral Blood Flow in Alzheimer’s Disease
- 1 December 2005
- journal article
- Published by S. Karger AG in Dementia and Geriatric Cognitive Disorders
- Vol. 21 (1), 16-21
- https://doi.org/10.1159/000089215
Abstract
To investigate the association between delusions and cerebral functional deficits in Alzheimer's disease (AD), we evaluated probable AD patients with and without delusions. Functional brain imaging was performed by single photon emission computed tomography with technetium-99m-labeled ethyl cysteinate dimer (99mTc-ECD) in 64 AD patients and 76 age-matched normal healthy volunteers. SPECT data were analyzed by statistical parametric mapping. In AD patients, no differences were found in age and cognitive activities between those with (n = 25) and without (n = 39) delusions. Compared with normal healthy volunteers, AD patients had significantly decreased perfusion in the posterior cingulate gyri, precunei, and parietal association cortex. Moreover, in the patients with delusions, perfusion was significantly decreased in the frontal lobe with right side dominance. In the comparison between the patients with and without delusions, the patients with delusions had significantly decreased perfusion in the prefrontal cortex, anterior cingulate gyri, inferior to middle temporal cortices, and parietal cortex of the right hemisphere (p < 0.01). The functional deficits in the right hemisphere may be the cause of delusions in AD.Keywords
This publication has 25 references indexed in Scilit:
- Delusions of Japanese patients with Alzheimer's diseaseInternational Journal of Geriatric Psychiatry, 2003
- Delusional Thoughts and Regional Frontal/Temporal Cortex Metabolism in Alzheimer’s DiseaseAmerican Journal of Psychiatry, 2003
- Hallucinations, delusions, and cognitive decline in Alzheimer's diseaseJournal of Neurology, Neurosurgery & Psychiatry, 2000
- Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's diseaseAnnals of Neurology, 1997
- Neuropsychiatric and neuropsychological correlates of delusions in Alzheimer's diseasePsychological Medicine, 1995
- The Neuropsychiatric InventoryNeurology, 1994
- Posterior cingulate cortex in Alzheimer's diseaseThe Lancet, 1994
- Predictors of nursing home placement in patients with alzheimer's diseaseInternational Journal of Geriatric Psychiatry, 1993
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975