Interaction of Bradykinin with Substance P on Vascular Permeability and Pain Response
Open Access
- 1 January 1986
- journal article
- Published by Elsevier BV in The Japanese Journal of Pharmacology
- Vol. 41 (3), 427-429
- https://doi.org/10.1254/jjp.41.427
Abstract
Combination of bradykinin with substance P exerted synergistic effects on vascular permeability and pain response in mouse paw. Denervation of sciatic nerve reduced significantly bradykinin-induced vascular permeability, suggesting the involvement of sensory nerves. The bradykinin-induced vascular permeability was also reduced by intravenous injection of a substance P-antagonist. The results suggest that neuronal substance P takes part in the action of bradykinin on inflammation and pain sensation.Keywords
This publication has 5 references indexed in Scilit:
- Pharmacological study of formalin-induced inflammatory pain response.Japanese Journal of Oral Biology, 1985
- A modified formalin test for measuring analgesia in mice.Japanese Journal of Oral Biology, 1984
- Bradykinin contracts the pupillary sphincter and evokes ocular inflammation through release of neuronal substance PEuropean Journal of Pharmacology, 1983
- DECREASE OF SUBSTANCE P IN PRIMARY AFFERENT NEURONES AND IMPAIRMENT OF NEUROGENIC PLASMA EXTRAVASATION BY CAPSAICINBritish Journal of Pharmacology, 1980
- Interactions of substance P with putative mediators of inflammation and ATPEuropean Journal of Pharmacology, 1977