Evaluation of healing and antimicrobiological effects of herbal therapy on venous leg ulcer: pilot study
- 16 July 2009
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 24 (2), 277-282
- https://doi.org/10.1002/ptr.2931
Abstract
Venous leg ulcers represent a significant public health problem that will increase as the population ages. Numerous herbs and their extracts are potentially conducive to wound healing, including the ability to serve as an antimicrobial, antifungal, astringent, etc. A total of 32 patients with venous leg ulcers were randomized into two groups: a group with herbal therapy treatment (PT) (17 patients) and a control group (C) (15 patients). The investigation focused on five controls of parameter changes important for ulcer healing and the control of microbiological flora. Within‐treatment analysis of the PT group showed that, following herbal therapy treatment, there was a significant decrease in the scores of surface leg ulcer and venous leg ulcer after week 7 of treatment (p < 0.05). In group C following topical antibiotic treatment there was no significant decrease in the surface leg ulcer. Comparing the results of decreased venous leg ulcer surface of the) PT group with the C group showed a significant difference at p < 0.05 after week 7 of treatment. The number of different types of isolated bacterial species decreased significantly (p < 0.05) after the use of herbal preparations. The results of this pilot study demonstrate the healing and antimicrobiological effects of herbal therapy on non‐infected venous leg ulcer. Copyright © 2009 John Wiley & Sons, Ltd.Keywords
This publication has 19 references indexed in Scilit:
- Der wundheilende Effekt einer Symphytum-Herba-Extrakt-Creme (Symphytum × uplandicum Nyman): Ergebnisse einer randomisierten, kontrollierten DoppelblindstudieWiener Medizinische Wochenschrift, 2007
- Living with leg ulceration: a synthesis of qualitative researchJournal of Advanced Nursing, 2007
- Medicinal plants used in Kırklareli Province (Turkey)Journal of Ethnopharmacology, 2007
- Multiple bacterial species reside in chronic wounds: a longitudinal studyInternational Wound Journal, 2006
- MICROBIOLOGICAL PROFILE OF CHRONIC ULCERS OF THE LOWER LIMB: A PROSPECTIVE OBSERVATIONAL COHORT STUDYAnz Journal of Surgery, 2006
- Venous ulcer: epidemiology, physiopathology, diagnosis and treatmentInternational Journal of Dermatology, 2005
- Wound Microbiology and Associated Approaches to Wound ManagementClinical Microbiology Reviews, 2001
- The effect of bacteria on leg ulcer healingBritish Journal of Community Nursing, 2001
- COMPLEMENTARY AND ALTERNATIVE MEDICINEDermatologic Clinics, 2000
- Prevalence of varicose veins and chronic venous insufficiency in men and women in the general population: Edinburgh Vein StudyJournal of Epidemiology and Community Health, 1999