Laser doppler flowmetry for estimation of bone blood flow: Studies of reproducibility and correlation with microsphere technique
- 1 July 1993
- journal article
- research article
- Published by Wiley in Journal of Orthopaedic Research
- Vol. 11 (4), 573-580
- https://doi.org/10.1002/jor.1100110412
Abstract
The blood flow in the femoral condyles of six pigs was measured by the microsphere technique and by laser Doppler flowmetry (LDF) before and after clamping of the external iliac artery. A significant decrease in the bone blood flow was found with both microsphere and LDF measurements, and a high correlation was found between the two methods. After release of the arterial clamp, the LDF values rapidly returned to approximately the same values as before clamping. In a second part of the study, the LDF output signal was studied in the intertrochanteric area of eight patients. The reproducibility of two LDF measurements at the same location was within 15%. The temporal variability of the LDF signal during 10 min of recording showed only slight variations. It is concluded that LDF is relative in nature and that the mean LDF output signal is suitable for monitoring dynamic responses of the bone blood flow to various stimuli. Several consecutive measurements have to be performed if the blood flow at different locations of a specific bone are to be compared with each other.Keywords
This publication has 24 references indexed in Scilit:
- Effect of intracapsular hyperpressure on femoral head blood flow: Laser Doppler flowmetry in dogsActa Orthopaedica, 1991
- Canine bone blood flow estimated with microspheresJournal of Orthopaedic Research, 1989
- Hemodynamic effects of knee-joint tamponade99mTc-diphosphonate scintimetry in growing dogsActa Orthopaedica, 1989
- Repeated measurements of cerebral blood flow in rats. Comparisons between the hydrogen clearance method and laser Doppler flowmetryActa Physiologica Scandinavica, 1988
- Cutaneous microcirculation and blood rheology following cardiopulmonary bypass: Laser Doppler Flowmetric and Blood Cell Rheologic StudiesScandinavian Journal of Thoracic and Cardiovascular Surgery, 1988
- Assessment of myocardial perfusion with laser doppler flowmetry: An Experimental Study on Porcine HeartScandinavian Journal of Thoracic and Cardiovascular Surgery, 1988
- Laser doppler flowmetry for bone blood flow measurement: Correlation with microsphere estimates and evaluation of the effect of intracapsular pressure on femoral head blood flowJournal of Orthopaedic Research, 1986
- Blood Flow in the Juvenile Hip in Relation to Changes of the Intraarticular Pressure: An Experimental Investigation in DogsActa Orthopaedica, 1983