Striatal Involvement in Human Alcoholism and Alcohol Consumption, and Withdrawal in Animal Models
- 25 May 2011
- journal article
- review article
- Published by Wiley in Alcohol: Clinical and Experimental Research
- Vol. 35 (10), 1739-1748
- https://doi.org/10.1111/j.1530-0277.2011.01520.x
Abstract
Background: Different regions of the striatum may have distinct roles in acute intoxication, alcohol seeking, dependence, and withdrawal. Methods: The recent advances are reviewed and discussed in our understanding of the role of the dorsolateral striatum (DLS), dorsomedial striatum (DMS), and ventral striatum in behavioral responses to alcohol, including alcohol craving in abstinent alcoholics, and alcohol consumption and withdrawal in rat, mouse, and nonhuman primate models. Results: Reduced neuronal activity as well as dysfunctional connectivity between the ventral striatum and the dorsolateral prefrontal cortex is associated with alcohol craving and impairment of new learning processes in abstinent alcoholics. Within the DLS of mice and nonhuman primates withdrawn from alcohol after chronic exposure, glutamatergic transmission in striatal projection neurons is increased, while GABAergic transmission is decreased. Glutamatergic transmission in DMS projection neurons is also increased in ethanol withdrawn rats. Ex vivo or in vivo ethanol exposure and withdrawal causes a long‐lasting increase in NR2B subunit‐containing NMDA receptor activity in the DMS, contributing to ethanol drinking. Analyses of neuronal activation associated with alcohol withdrawal and site‐directed lesions in mice implicate the rostroventral caudate putamen, a ventrolateral segment of the DMS, in genetically determined differences in risk for alcohol withdrawal involved in physical association of the multi‐PDZ domain protein, MPDZ, with 5‐HT2C receptors and/or NR2B. Conclusions: Alterations of dopaminergic, glutamatergic, and GABAergic signaling within different regions of the striatum by alcohol is critical for alcohol craving, consumption, dependence, and withdrawal in humans and animal models.Keywords
This publication has 87 references indexed in Scilit:
- Substantia nigra pars reticulata is crucially involved in barbiturate and ethanol withdrawal in miceBehavioural Brain Research, 2011
- Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA/2J and C57BL/6J miceAlcohol, 2009
- Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual ActionNeuropsychopharmacology, 2009
- Alcohol Exposure Alters NMDAR Function in the Bed Nucleus of the Stria TerminalisNeuropsychopharmacology, 2009
- The role of GABAA receptors in the acute and chronic effects of ethanol: a decade of progressPsychopharmacology, 2009
- MRI-guided dissection of the nonhuman primate brain: A case studyMethods, 2009
- Excessive alcohol consumption is blocked by glial cell line–derived neurotrophic factorAlcohol, 2009
- Neurobiological mechanisms for opponent motivational processes in addictionPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2008
- Neuropharmacology of alcohol addictionBritish Journal of Pharmacology, 2008
- Decreased Volume of the Brain Reward System in AlcoholismBiological Psychiatry, 2008