Contemporary Tools for the Diagnosis and Management of Invasive Mycoses
Open Access
- 1 August 2006
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 43 (Supplement), S15-S27
- https://doi.org/10.1086/504491
Abstract
Invasive fungal infections have become a major cause of morbidity and mortality over the past 3 decades. Organ transplantation, the use of aggressive chemotherapy, and the availability and widespread use of immunosuppressive treatments for many medical ailments have resulted in large populations of patients who are at risk for fungal disease. Early diagnosis and prompt therapy are instrumental to successful treatment of these infections, but conventional methods for diagnosis of fungal disease are slow and lack sensitivity. Important advances in diagnosing invasive mycoses, particularly in laboratory-based testing, have been realized over the years. Antigen-based assays, new laboratory methods for identification of fungi, and reference guidelines for susceptibility testing have been developed and validated for use in clinical laboratories. We review these technological advances and our understanding of their clinical application and impact.Keywords
This publication has 85 references indexed in Scilit:
- CHROMagar Candida Medium for Direct Susceptibility Testing of Yeast from Blood CulturesJournal of Clinical Microbiology, 2005
- Rare and Emerging Opportunistic Fungal Pathogens: Concern for Resistance beyondCandida albicansandAspergillus fumigatusJournal of Clinical Microbiology, 2004
- Routine Use of a Commercial Test, GLABRATA RTT, for Rapid Identification of Candida glabrata in Six LaboratoriesJournal of Clinical Microbiology, 2004
- Infections due to emerging and uncommon medically important fungal pathogensClinical Microbiology & Infection, 2004
- Fluorescence In Situ Hybridization with Peptide Nucleic Acid Probes for Rapid Identification of Candida albicans Directly from Blood Culture BottlesJournal of Clinical Microbiology, 2002
- LABORATORY DIAGNOSIS OF BACTEREMIA AND FUNGEMIAInfectious Disease Clinics of North America, 2001
- Mycoses in the transplanted patientMedical Mycology, 2000
- Update on detection of bacteremia and fungemiaClinical Microbiology Reviews, 1997
- Laboratory Methods for the Diagnosis and Confirmation of Systemic MycosesClinical Infectious Diseases, 1992
- Use of Calcofluor White in Clinical MycologyLaboratory Medicine, 1984