Synthesis and anti-microbial activities of choline-like quaternary ammonium chlorides
- 1 November 2003
- journal article
- Published by Elsevier BV in European Journal of Medicinal Chemistry
- Vol. 38 (11-12), 1035-1042
- https://doi.org/10.1016/j.ejmech.2003.09.004
Abstract
New choline-like quaternary ammonium chlorides were obtained. The work-up procedure of synthesis was quick and efficient. The obtained chlorides showed anti-microbial activities. Quaternary ammonium chlorides derivatives of deanol esters exhibited strong activity and wide anti-bacterial spectra, similar to the activity of benzalkonium chloride. The relationship between chemical structure and anti-microbial activity was analyzed by the QSAR method.Keywords
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