Functional Polymorphisms inCOX-2Gene Are Correlated with the Risk of Oral Cancer
Open Access
- 21 April 2015
- journal article
- research article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2015, 1-12
- https://doi.org/10.1155/2015/580652
Abstract
Background. This meta-analysis investigated the association between functional COX-2 gene polymorphisms and the risk of oral cancer. Methods. Several electronic databases were searched for published studies using combinations of keywords related to COX-2 gene polymorphisms and oral cancer. After selection of relevant studies, following strict inclusion and exclusion criteria, data was performed using STATA 12.0 software. Results. We retrieved 83 studies from database search using specific search terms. After multiple rounds of selection and elimination, 7 studies were finally identified as suitable to be included in our present meta-analysis, based on their relevance and data integrity. These 7 studies contained a combined total of 2,296 oral cancer patients and 3,647 healthy controls. Our findings demonstrated thatKeywords
This publication has 29 references indexed in Scilit:
- COX-2-765G>C Polymorphism Increases the Risk of Cancer: A Meta-AnalysisPLOS ONE, 2013
- Association between COX-2 rs2745557 polymorphism and prostate cancer risk: a systematic review and meta-analysisBMC Immunology, 2012
- Role ofcyclooxygenase-2gene polymorphisms in pancreatic carcinogenesisWorld Journal of Gastroenterology, 2011
- Lycopene: features and potential significance in the oral cancer and precancerous lesionsJournal of Oral Pathology & Medicine, 2010
- Glycogen synthase kinase 3 beta: can it be a target for oral cancerMolecular Cancer, 2010
- Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathwaysCarcinogenesis: Integrative Cancer Research, 2009
- Cyclooxygenase‐2 gene polymorphisms reduce the risk of oral premalignant lesionsCancer, 2009
- Up-regulation of Inflammatory Signalings by Areca Nut Extract and Role of Cyclooxygenase-2 −1195G>A Polymorphism Reveal Risk of Oral CancerCancer Research, 2008
- Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tractCancer Causes & Control, 2007
- Comparison of Two Methods to Detect Publication Bias in Meta-analysisJAMA, 2006