Chromosome-wide linkage disequilibrium as a consequence of meiotic drive
Open Access
- 30 January 2007
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 104 (5), 1587-1592
- https://doi.org/10.1073/pnas.0605578104
Abstract
Adaptation by natural selection proceeds most efficiently when alleles compete solely on the basis of their effects on the survival and reproduction of their carriers. A major condition for this is equal Mendelian segregation, but meiotic drive can short-circuit this process. The evolution of drive often involves multiple, interacting genetic components, together with enhancers and suppressors of drive. Chromosomal inversions that suppress crossing over are also frequently associated with drive systems. This study investigates the effects of these processes on patterns of molecular evolution in the fly Drosophila recens, which is polymorphic for a driving X chromosome (XD). Whereas standard wild-type chromosomes exhibit high levels of polymorphism at multiple loci, all of the XD chromosomes effectively carry a single multilocus haplotype that spans at least 130 cM. The XD is associated with a complex set of inversions that completely suppresses recombination between the standard wild-type chromosome and XD in heterozygous females, which maintain nonrandom associations among loci that presumably interact epistatically for the expression of drive. The long-term costs of foregoing recombination may be substantial; in combination with its low equilibrium frequency, this makes the XD chromosome susceptible to the accumulation of deleterious mutations. Consistent with this, XD chromosomes are apparently fixed for a recessive mutation that causes female sterility. Thus, the XD in D. recens appears to be in chromosome-wide linkage disequilibrium and in the early stages of mutational degradation.This publication has 67 references indexed in Scilit:
- Asymmetrical Reinforcement and Wolbachia Infection in DrosophilaPLoS Biology, 2006
- Mechanisms of Genetic Exchange Within the Chromosomal Inversions of Drosophila pseudoobscuraGenetics, 2005
- Signature of Selective Sweep Associated With the Evolution of sex-ratio Drive in Drosophila simulansGenetics, 2004
- DnaSP, DNA polymorphism analyses by the coalescent and other methodsBioinformatics, 2003
- Reduced adaptation of a non-recombining neo-Y chromosomeNature, 2002
- The degeneration of Y chromosomesPhilosophical Transactions B, 2000
- The evolution of dosage-compensation mechanismsBioEssays, 2000
- Cheaters sometimes prosper: distortion of mendelian segregation by meiotic driveTrends in Genetics, 1993
- Analyzing Tables of Statistical TestsEvolution, 1989
- THE ESTIMATION OF MAP DISTANCES FROM RECOMBINATION VALUESAnnals of Eugenics, 1943