New Marine Cembrane-type Diterpenoids from the Okinawan Soft Coral Clavularia koellikeri
- 10 November 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 63 (12), 1647-1652
- https://doi.org/10.1021/np000309w
Abstract
Seven new marine diterpenoids having a cembrane skeleton were isolated from the Okinawan soft coral Clavularia koellikeri. Their structures were determined based on the results of spectroscopic analysis and chemical conversions. Compound 1 showed cytotoxic activity against human colorectal adenocarcinoma cells (DLD-1, IC50 4.2 μg/mL) and strong growth inhibition against human T lymphocytic leukemia cells (MOLT-4, IC50 0.9 μg/mL).Keywords
This publication has 2 references indexed in Scilit:
- Clavirins, a new type of marine oxylipins with growth-inhibitory activity from the Okinawan soft coral, Clavularia viridisTetrahedron Letters, 1999
- High-field FT NMR application of Mosher's method. The absolute configurations of marine terpenoidsJournal of the American Chemical Society, 1991