Measles Outbreak in a Fully Immunized Secondary-School Population
- 26 March 1987
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 316 (13), 771-774
- https://doi.org/10.1056/nejm198703263161303
Abstract
An outbreak of measles occurred among adolescents in Corpus Christi, Texas, in the spring of 1985, even though vaccination requirements for school attendance had been thoroughly enforced. Serum samples from 1806 students at two secondary schools were obtained eight days after the onset of the first case. Only 4.1 percent of these students (74 of 1806) lacked detectable antibody to measles according to enzymelinked immunosorbent assay, and more than 99 percent had records of vaccination with live measles vaccine. Stratified analysis showed that the number of doses of vaccine received was the most important predictor of antibody response. Ninety-five percent confidence intervals of seronegative rates were 0 to 3.3 percent for students who had received two prior doses of vaccine, as compared with 3.6 to 6.8 percent for students who had received only a single dose. After the survey, none of the 1732 seropositive students contracted measles. Fourteen of 74 seronegative students, all of whom had been vaccinated, contracted measles. In addition, three seronegative students seroconverted without experiencing any symptoms.Keywords
This publication has 13 references indexed in Scilit:
- Major Impediments to Measles EliminationAmerican Journal of Diseases of Children, 1985
- The use of IgM tests for analysis of the causes of measles vaccine failures: Experience gained in an epidemic in hungary in 1980 and 1981Journal of Medical Virology, 1984
- Further-Attenuated Measles Vaccine: Characteristics and UseClinical Infectious Diseases, 1983
- Persistence of Antibody in Human Subjects for 7 to 10 Years following Administration of Combined Live Attenuated Measles, Mumps, and Rubella Virus VaccinesExperimental Biology and Medicine, 1980
- Epidemic Measles in a Highly Vaccinated PopulationNew England Journal of Medicine, 1977
- A measles outbreak among adolescentsThe Journal of Pediatrics, 1977
- Impotency of live-virus vaccines as a result of improper handling in clinical practiceThe Journal of Pediatrics, 1974
- A clinical and serologic study of 103 children with measles vaccine failureThe Journal of Pediatrics, 1973
- Measles in Previously Vaccinated ChildrenAmerican Journal of Diseases of Children, 1972
- An Epidemic of Measles in Southern Greenland, 1951Acta Medica Scandinavica, 1953