Glutaminolysis yields a metabolic by-product that stimulates autophagy
Open Access
- 27 October 2010
- journal article
- Published by Taylor & Francis Ltd in Autophagy
- Vol. 6 (7), 968-970
- https://doi.org/10.4161/auto.6.7.13082
Abstract
Autophagy is an intracellular degradative pathway that plays key roles in the homeostatic turnover of long-lived or damaged proteins and organelles, and in the survival of cells during starvation or other stressful conditions. We have uncovered an unexpected link between glutamine (Gln) metabolism and the regulation of autophagy. Our findings indicate that ammonia, generated from Gln deamination in mitochondria, functions as an autocrine- and/or paracrine-acting stimulator of autophagic flux.Keywords
This publication has 1 reference indexed in Scilit:
- Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of AutophagyScience Signaling, 2010