Protein-based organelles in bacteria: carboxysomes and related microcompartments
Top Cited Papers
- 4 August 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Microbiology
- Vol. 6 (9), 681-691
- https://doi.org/10.1038/nrmicro1913
Abstract
Many bacteria contain intracellular microcompartments with outer shells that are composed of thousands of protein subunits and interiors that are filled with functionally related enzymes. These microcompartments serve as organelles by sequestering specific metabolic pathways in bacterial cells. The carboxysome, a prototypical bacterial microcompartment that is found in cyanobacteria and some chemoautotrophs, encapsulates ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and carbonic anhydrase, and thereby enhances carbon fixation by elevating the levels of CO2 in the vicinity of RuBisCO. Evolutionarily related, but functionally distinct, microcompartments are present in diverse bacteria. Although bacterial microcompartments were first observed more than 40 years ago, a detailed understanding of how they function is only now beginning to emerge.This publication has 66 references indexed in Scilit:
- Genomic and Biochemical Studies Demonstrating the Absence of an Alkane-Producing Phenotype in Vibrio furnissii M1Applied and Environmental Microbiology, 2007
- The Structure of Isolated Synechococcus Strain WH8102 Carboxysomes as Revealed by Electron CryotomographyJournal of Molecular Biology, 2007
- Long-Term Response toward Inorganic Carbon Limitation in Wild Type and Glycolate Turnover Mutants of the Cyanobacterium Synechocystis sp. Strain PCC 6803Plant Physiology, 2007
- PduL Is an Evolutionarily Distinct Phosphotransacylase Involved in B 12 -Dependent 1,2-Propanediol Degradation by Salmonella enterica Serovar Typhimurium LT2Journal of Bacteriology, 2007
- Characterization of the Carboxysomal Carbonic Anhydrase CsoSCA from Halothiobacillus neapolitanusJournal of Bacteriology, 2006
- Structure of Halothiobacillus neapolitanus Carboxysomes by Cryo-electron TomographyJournal of Molecular Biology, 2006
- The Plant-Like C2 Glycolate Cycle and the Bacterial-Like Glycerate Pathway Cooperate in Phosphoglycolate Metabolism in CyanobacteriaPlant Physiology, 2006
- The Pfam protein families databaseNucleic Acids Research, 2004
- Quasi-equivalent viruses: a paradigm for protein assembliesJournal of Molecular Biology, 1997
- Physical Principles in the Construction of Regular VirusesCold Spring Harbor Symposia on Quantitative Biology, 1962