Shear wave elastography in the diagnosis of thyroid nodules: feasibility in the case of coexistent chronic autoimmune Hashimoto’s thyroiditis
- 7 December 2011
- journal article
- Published by Wiley in Clinical Endocrinology
- Vol. 76 (1), 137-141
- https://doi.org/10.1111/j.1365-2265.2011.04170.x
Abstract
ShearWave™ Elastography (SWE) is real-time, quantitative and user-independent technique, recently introduced in the diagnostic work-up of thyroid nodules. Hashimoto's thyroiditis (HT), characterized by variable degrees of lymphocytic infiltration and fibrosis, might affect shear wave propagation. The aim of this study was to assess the feasibility of SWE in cytologically benign thyroid nodules within both Hashimoto's and nonautoimmune thyroid glands. The effect of autoimmunity on the gland stiffness was also evaluated. longitudinal study in a single centre. SWE was performed in 75 patients with a benign thyroid nodule at cytology: 33 with Hashimoto's thyroiditis (HT group) and 42 with uni- or multi-nodular goitre, negative for thyroid autoimmunity (non-HT group). The elasticity index (EI) of the extra-nodular tissue was greater, though not statistically significant, in the HT than in the non-HT group (24·0 ± 10·5 kPa vs 20·8 ± 10·4 kPa; P = 0·206). However, the EI of extra-nodular tissue was related to the TPOAb titre in the HT group (P = 0·02) and was significantly higher in patients with HT receiving L-thyroxine than in the euthyroid subjects (P = 0·02). The EI of thyroid nodules was similar in HT and non-HT groups. In both groups, the stiffness of nodules was significantly higher than that of the embedding tissue. Our data indicate that SWE correctly defines the elasticity of thyroid nodules independently from the coexistence of autoimmune thyroiditis, always being able to differentiate nodular tissue from the surrounding parenchyma. In HT, the stiffness of extra-nodular tissue increases in relation to both the thyroid antibody titre and the degree of impairment of thyroid function.Keywords
This publication has 32 references indexed in Scilit:
- Shear Wave Elastography: A New Ultrasound Imaging Mode for the Differential Diagnosis of Benign and Malignant Thyroid NodulesJournal of Clinical Endocrinology & Metabolism, 2010
- The Association Between Thyroid Carcinoma and Hashimoto's Thyroiditis: The Ultrasonographic and Histopathologic Characteristics of Malignant NodulesThyroid®, 2010
- Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid CancerThyroid®, 2009
- Elastosonographic evaluation of thyroid nodules in acromegalyActa Endocrinologica, 2009
- Thyroid nodules: a review of current guidelines, practices, and prospectsActa Endocrinologica, 2008
- Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluationCancer, 2007
- Increased Incidence of Well-Differentiated Thyroid Cancer Associated with Hashimoto Thyroiditis and the Role of the PI3k/Akt PathwayJournal of the American College of Surgeons, 2007
- High prevalence of suspicious cytology in thyroid nodules associated with positive thyroid autoantibodiesActa Endocrinologica, 2005
- A 64-Year-Old Woman With a Thyroid NoduleJama-Journal Of The American Medical Association, 2004
- Volumetrie der Schilddrüsenlappen mittels Real-time-Sonographie* 1Deutsche Medizinische Wochenschrift (1946), 1981