Intraocular VEGF Level as a Risk Factor for Postoperative Complications after Vitrectomy for Proliferative Diabetic Retinopathy
- 1 September 2012
- journal article
- research article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Opthalmology & Visual Science
- Vol. 53 (10), 6403-6410
- https://doi.org/10.1167/iovs.12-10367
Abstract
Purpose.: To investigate whether vitreous and aqueous humor concentrations of vascular endothelial growth factor (VEGF) predict postoperative complications after vitrectomy for proliferative diabetic retinopathy (PDR). Methods.: Sixty eyes of 52 patients with PDR who underwent vitrectomy were enrolled. Vitreous and aqueous humor were obtained from eyes with PDR during primary vitrectomy and the levels of VEGF were measured using a commercial flow cytometer. Patients were followed for more than 6 months after surgery. Demographic data and both intraoperative and postoperative findings were recorded. The relationship between VEGF levels in ocular fluids and the main postoperative complications of early vitreous hemorrhage (VH) and neovascular glaucoma (NVG) occurring during follow-up was analyzed. Logistic regression analyses were performed to examine risk factors related to postoperative complications. Results.: Early VH occurred in 25%, and NVG occurred in 8% of 60 eyes. The vitreous levels of VEGF were significantly higher (P = 0.015) in eyes with early VH than in those without. The aqueous humor and vitreous levels of VEGF were significantly higher (P = 0.005 and P = 0.001, respectively) in eyes with NVG than in those without. Axial length was significantly shorter in eyes with early VH than in those without (P = 0.028). Multivariate logistic regression analysis showed that the higher vitreous VEGF level was associated with a risk of early VH after vitrectomy for PDR (odds ratio, 5.1; P = 0.020). Conclusions.: High intraocular VEGF level at the time of primary vitrectomy in patients with PDR was identified as a significant risk factor for postoperative early VH.Keywords
This publication has 20 references indexed in Scilit:
- The Effect of Adjunctive Intravitreal Bevacizumab for Preventing Postvitrectomy Hemorrhage in Proliferative Diabetic RetinopathyOphthalmology, 2011
- Reducing the incidence of early postoperative vitreous haemorrhage by preoperative intravitreal bevacizumab in vitrectomy for diabetic tractional retinal detachmentActa Ophthalmologica, 2010
- CORRELATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR WITH CHEMOKINES IN THE VITREOUS IN DIABETIC RETINOPATHYRetina, 2010
- Intravitreal injection of bevacizumab and triamcinolone acetonide at the end of vitrectomy for diabetic vitreous hemorrhage: a comparative studyAlbrecht von Graefes Archiv für Ophthalmologie, 2009
- Intravitreal Bevacizumab for Prevention of Early Postvitrectomy Hemorrhage in Diabetic PatientsA Randomized Clinical TrialOphthalmology, 2009
- Microincision Vitrectomy Surgery and Intravitreal Bevacizumab as a Surgical Adjunct to Treat Diabetic Traction Retinal DetachmentOphthalmology, 2009
- Intravitreal Long-Acting Gas in the Prevention of Early Postoperative Vitreous Hemorrhage in Diabetic VitrectomyOphthalmology, 2007
- Vitreous Levels of Vascular Endothelial Growth Factor and Intercellular Adhesion Molecule 1 Are Related to Diabetic Macular EdemaOphthalmology, 2005
- Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal DisordersNew England Journal of Medicine, 1994
- Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic RetinopathyAmerican Journal of Ophthalmology, 1994