Growth Factors in Induction of Epithelial-Mesenchymal Transition and Metastasis
- 3 November 2010
- journal article
- research article
- Published by S. Karger AG in Cells Tissues Organs
- Vol. 193 (1-2), 85-97
- https://doi.org/10.1159/000320360
Abstract
Epithelial to mesenchymal transition (EMT) has gained widespread acceptance over recent years as a mechanism by which normally sessile epithelial tumour cells can move away from the primary tumour and metastasize. This review article examines the role of a number of growth factors in inducing EMT, and the reverse process mesenchymal to epithelial transition. Unique and common intracellular signalling pathways are highlighted. A comprehensive understanding of the regulation of EMT will be critical in manipulating this process to develop novel anti-metastasis therapies.This publication has 86 references indexed in Scilit:
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