Mendelian randomization: A novel test of the gateway hypothesis and models of gene–environment interplay
- 1 June 2007
- journal article
- Published by Cambridge University Press (CUP) in Development and Psychopathology
- Vol. 19 (4), 1181-1195
- https://doi.org/10.1017/s0954579407000612
Abstract
To determine if drinking behavior in adolescence provides a “gateway” leading to the misuse of other psychoactive substances and antisocial behavior, we genotyped 180 Asian adolescent adoptees to determine if they inherited the deficient from of the aldehyde dehydrogenase 2 (ALDH2) enzyme that is important in the metabolism of alcohol. Based on the gateway model, we hypothesized that those with normal enzyme activity (70% of the sample) who began to misuse alcohol would also misuse other drugs and display antisocial tendencies. Those with the enzyme deficiency (30%), because they experience unpleasant side effects associated with drinking, were expected to show less evidence of alcohol misuse and thus be less likely to progress to the misuse of other substances or engage in antisocial acts. Consistent with previous research, we found that ALDH2 deficiency was significantly associated with lower rates of drinking and getting drunk but not with ever having tried alcohol. Contrary to the gateway model, we found no evidence that ALDH2 deficiency was associated with lower rates of nonalcohol substance use or antisociality. Finally, in an examination of factors that may moderate the impact of the metabolic protection because of ALDH2 deficiency, we identified siblings rather than parents as the major source of familial environmental effect on adolescent drinking.Keywords
This publication has 57 references indexed in Scilit:
- The Association of Early Adolescent Problem Behavior and Adult Psychopathology: A Multivariate Behavioral Genetic PerspectiveBehavior Genetics, 2006
- TESTING THE GATEWAY HYPOTHESISAddiction, 2006
- Externalizing psychopathology in adulthood: A dimensional-spectrum conceptualization and its implications for DSM-V.Journal of Abnormal Psychology, 2005
- ALDH2 Status and Conduct Disorder Mediate the Relationship Between Ethnicity and Alcohol Dependence in Chinese, Korean, and White American College Students.Journal of Abnormal Psychology, 2004
- the relationship between drinking and violence in an adolescent population: does gender matter?Deviant Behavior, 2002
- Testing hypotheses on specific environmental causal effects on behavior.Psychological Bulletin, 2001
- Close friend and group influence on adolescent cigarette smoking and alcohol use.Developmental Psychology, 1997
- Age at onset of alcohol use and its association with DSM-IV alcohol abuse and dependence: results from the national longitudinal alcohol epidemiologic surveyJournal of Substance Abuse, 1997
- Problem Behavior and Psychosocial Development: A Longitudinal Study of Youth.Contemporary Sociology: A Journal of Reviews, 1978
- Self‐reported Delinquency among Schoolboys, and their Attitudes to the PoliceBritish Journal of Social and Clinical Psychology, 1967