Association of paternal age with prevalence of selected birth defects
- 21 November 2006
- journal article
- Published by Wiley in Birth Defects Research Part A: Clinical and Molecular Teratology
- Vol. 79 (1), 27-34
- https://doi.org/10.1002/bdra.20316
Abstract
BACKGROUND: Unlike maternal age, the effect of paternal age on birth defect prevalence has not been well examined. We used cases from the Texas birth defect registry, born during 1996–2002, to evaluate the association of paternal age with the prevalence of selected structural birth defects. METHODS: Poisson regression was used to calculate prevalence ratios (PRs) and 95% confidence intervals (CIs) associated with paternal age for each birth defect, adjusting for maternal age, race/ethnicity, and parity. RESULTS: Relative to fathers ages 25–29 years, fathers 20–24 years of age were more likely to have offspring with gastroschisis (PR 1.47, 95% CI: 1.12–1.94), and fathers 40+ years old were less likely to have offspring with trisomy 13 (PR 0.40, 95% CI: 0.16–0.96). No association was seen between paternal age and prevalence of anencephaly and encephalocele. A selection bias was observed for the other birth defects in which cases of younger fathers were more often excluded from study. CONCLUSIONS: In studies of birth defect risk and paternal age, the source of information may affect the validity of findings. Birth Defects Research (Part A) 2007.Keywords
This publication has 26 references indexed in Scilit:
- Down syndrome, paternal age and education: comparison of California and the Czech RepublicBMC Public Health, 2005
- Primary prevention of Down's syndromeInternational Journal of Medical Sciences, 2005
- The Paternal-Age Effect in Apert Syndrome Is Due, in Part, to the Increased Frequency of Mutations in SpermAmerican Journal of Human Genetics, 2003
- Mystery of the mutagenic maleNature, 2002
- The origins, patterns and implications of human spontaneous mutationNature Reviews Genetics, 2000
- 4 The Origin of Numerical Chromosome AbnormalitiesAdvances in genetics, 1995
- Young maternal age and smoking during pregnancy as risk factors for gastroschisisTeratology, 1993
- Maternal age and birth defects: a population studyThe Lancet, 1991
- TRISOMY IN MANAnnual Review of Genetics, 1984
- Down syndrome associated with father's age in Norway.Journal of Medical Genetics, 1981