Intracellular Signaling by 14-hydroxy-4,14- Retro -Retinol
- 13 December 1991
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 254 (5038), 1654-1656
- https://doi.org/10.1126/science.1749937
Abstract
In mammals, retinol is the precursor for retinoids, which affect various aspects of morphogenesis and development. However, B lymphocytes, although retinol-dependent, do not use retinoic acid as mediator. Retinol is metabolized by B lymphocytes and other cell lines to optically active 14-hydroxy-4,14-retro-retinol; it is this compound that mediates the growth control. Thus another second messenger molecule, in addition to retinoic acid and retinal, is derived from retinol.This publication has 13 references indexed in Scilit:
- Nuclear receptor that identifies a novel retinoic acid response pathwayNature, 1990
- Retinol is essential for growth of activated human B cells.The Journal of Experimental Medicine, 1990
- Identification of a receptor for the morphogen retinoic acidNature, 1987
- A human retinoic acid receptor which belongs to the family of nuclear receptorsNature, 1987
- General method for determining absolute configuration of acyclic allylic alcoholsJournal of the American Chemical Society, 1982
- Purification of a bovine counterpart to human prealbumin and its interaction with a bovine retinol-binding proteinBiochimica et Biophysica Acta (BBA) - Protein Structure, 1977
- The influence of allylic oxygen on the π → π* CD of certain chromophoresTetrahedron, 1971
- Molecular Basis of Visual ExcitationScience, 1968
- Conversion of Vitamin A Acetate to Retrovitamin A AcetateJournal of the American Chemical Society, 1955
- Synthesis of Polyenes. I. Retrovitamin A Methyl Ether. Spectral Relationships between the β-Ionylidene and Retroionylidene SeriesJournal of the American Chemical Society, 1952