Association of Cholesteryl Ester Transfer Protein– Taq IB Polymorphism With Variations in Lipoprotein Subclasses and Coronary Heart Disease Risk
- 1 May 2000
- journal article
- other
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 20 (5), 1323-1329
- https://doi.org/10.1161/01.atv.20.5.1323
Abstract
—Cholesteryl ester transfer protein (CETP) facilitates the exchange of triglycerides and cholesteryl esters between lipoprotein particles, a key step in reverse cholesterol transport in humans. Variations at the CETP locus have been shown to be determinants of the levels and activity of CETP and high density lipoprotein (HDL) plasma concentration. The associations of the common CETP polymorphism, TaqIB in intron 1, with lipoprotein levels and particle size distribution, CETP activity, and coronary heart disease (CHD) risk were examined in a population-based sample of 1411 men and 1505 women from the Framingham Offspring Study. The B2 allele frequency was 0.444 in men and 0.433 in women, and its presence was significantly (P<0.05) associated with decreased CETP activity. B1B1 men had lower HDL cholesterol (HDL-C) levels (1.07 mmol/L) compared with B1B2 (1.14 mmol/L) and B2B2 (1.18 mmol/L) men (P<0.001). Likewise, B1B1 women had lower HDL-C levels (1.40 mmol/L) compared with B1B2 (1.46 mmol/L) and B...Keywords
This publication has 46 references indexed in Scilit:
- A polymorphic site in the 3′ untranslated region of the cholesteryl ester transfer protein (CETP) gene is associated with low CETP activityAtherosclerosis, 1996
- Cholesteryl ester transfer protein: friend or foe?JCI Insight, 1996
- HDL Heterogeneity and AtherosclerosisCritical Reviews in Clinical Laboratory Sciences, 1996
- Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol.JCI Insight, 1994
- Relation of polymorphisms in the cholesteryl ester transfer protein gene to transfer protein activity and plasma lipoprotein levels in alcohol drinkersAtherosclerosis, 1994
- Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences.JCI Insight, 1992
- Compound heterozygote of cholesteryl-ester transfer protein deficiency in a patient with hyperalphalipoproteinemiaAtherosclerosis, 1992
- Serum lipoprotein lipid concentration and composition in homozygous and heterozygous patients with cholesteryl ester transfer protein deficiencyAtherosclerosis, 1991
- High-Density Lipoprotein — The Clinical Implications of Recent StudiesNew England Journal of Medicine, 1989
- The framingham offspring study. Design and preliminary dataPreventive Medicine, 1975