The spine in Paget’s disease
Open Access
- 5 April 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Skeletal Radiology
- Vol. 36 (7), 609-626
- https://doi.org/10.1007/s00256-006-0270-6
Abstract
Paget’s disease (PD) is a chronic metabolically active bone disease, characterized by a disturbance in bone modelling and remodelling due to an increase in osteoblastic and osteoclastic activity. The vertebra is the second most commonly affected site. This article reviews the various spinal pathomechanisms and osseous dynamics involved in producing the varied imaging appearances and their clinical relevance. Advanced imaging of osseous, articular and bone marrow manifestations of PD in all the vertebral components are presented. Pagetic changes often result in clinical symptoms including back pain, spinal stenosis and neural dysfunction. Various pathological complications due to PD involvement result in these clinical symptoms. Recognition of the imaging manifestations of spinal PD and the potential complications that cause the clinical symptoms enables accurate assessment of patients prior to appropriate management.Keywords
This publication has 91 references indexed in Scilit:
- Management of Paget's disease of boneRheumatology, 2004
- Quantification of Skeletal Kinetic Indices in Paget's Disease Using Dynamic18F-Fluoride Positron Emission TomographyJournal of Bone and Mineral Research, 2002
- Paget's disease of bone and unvaccinated dogsBone, 1996
- On the Trail of Paramyxoviruses in Paget??s Disease of BoneClinical Orthopaedics and Related Research, 1987
- Pagetic ArthritisClinical Orthopaedics and Related Research, 1986
- Radiographical and Pathological Assessment of the Activity of Paget??s Disease of BonePublished by Ovid Technologies (Wolters Kluwer Health) ,1977
- Ossification in extradural fat in Paget's disease of the spineBritish Journal of Surgery, 1975
- PAGET'S DISEASE OF BONE: INCIDENCE AND SUBCLINICAL FORMSThe Lancet, 1956
- Über Ostitis deformans PagetVirchows Archiv, 1932
- THE OCCURRENCE IN OSTEITIS DEFORMANS OF LESIONS OF THE CENTRAL NERVOUS SYSTEM, WITH A REPORT OF FOUR CASESBrain, 1923