Epidemiologic Association BetweenFUT2Secretor Status and Severe Rotavirus Gastroenteritis in Children in the United States
Open Access
- 1 November 2015
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA Pediatrics
- Vol. 169 (11), 1040-1045
- https://doi.org/10.1001/jamapediatrics.2015.2002
Abstract
Histo-blood group antigens (HBGAs) are carbohydrates expressed on the mucosal epithelia of human respiratory, genitourinary, and digestive tracts that serve as host receptor sites necessary for bacterial or viral attachment and cellular entry and, therefore, infection. Their production is encoded by gene families expressing the ABO (A/B enzymes), secretor (α [1,2]-fucosyltransferase 2, or FUT2), and Lewis-type (FUT3) antigens. Single-nucleotide polymorphisms (SNPs) can inactivate the expression of these products. Individuals with genetically inactivated FUT2 production are termed nonsecretors (eFigure 1 in the Supplement).This publication has 31 references indexed in Scilit:
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