Failure of Cilostazol in the Prevention of Ventricular Fibrillation in a Patient with Brugada Syndrome
- 14 September 2005
- journal article
- case report
- Published by Wiley in Journal of Cardiovascular Electrophysiology
- Vol. 17 (2), 210-212
- https://doi.org/10.1111/j.1540-8167.2005.00290.x
Abstract
The ECG appearance in Brugada syndrome is caused by failure of the dome of the action potential to develop. Increased activity of the I(to) current in epicardial cells generates a transmural gradient with repolarization dispersion between the epicardium and the endocardium in the right ventricular wall, thus favoring the development of VF by a phase 2 reentry mechanism. The efficacy of cilostazol for the management of these arrhythmias has been reported. This drug is a phosphodiesterase inhibitor with positive chronotropic properties, thus blocking outward potassium currents I(to) in the myocardial tissue. We present a patient with Brugada syndrome with an implantable cardioverter defibrillator (ICD), who suffered multiple ICD discharges due to VF during therapy with this drug.Keywords
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