Physiological Evidence for Habenula as Major Link Between Forebrain and Midbrain Raphe
- 1 July 1977
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 197 (4298), 89-91
- https://doi.org/10.1126/science.194312
Abstract
Induction of early lymphocyte differentiation was studied in vitro in fractionated bone marrow cells of newly hatched chickens, with alloantiserums to identify newly differentiated B cells (Bu-1+) and T cells (Th-1+). Thymus extract induced selective T cell differentiation; the activity of the extract corresponds to that of thymopoietin. Bursal extract induced both B cell and T cell differentiation, but at lower concentrations B cell differentiation was always greater. This activity is ascribed to a lymphocyte-differentiating hormone of the bursa of Fabricius, for which the name bursopoietin is suggested.Keywords
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