The Association of Intrapartum Antibiotic Exposure With the Incidence and Antibiotic Resistance of Infantile Late-Onset Serious Bacterial Infections
- 1 September 2011
- journal article
- Published by SAGE Publications in Clinical Pediatrics
- Vol. 50 (9), 827-833
- https://doi.org/10.1177/0009922811406260
Abstract
Background. The widespread use of intrapartum antibiotics (IPA) has raised concerns regarding the adverse effects on the newborn. Objectives. To determine if IPA is associated with infantile late-onset serious bacterial infections (SBIs) and with antibiotic resistance. Patients and methods. From 2005 to 2009, data were prospectively collected for all infants born at our center, aged 7 to 90 days, who were hospitalized for fever. Cases included infants with culture-proven SBIs, and controls included infants without SBIs. Results. A total of 71 cases and 124 controls were included. IPA was documented in 11.3% of cases and in 7.3% of controls ( P = .34). Among cases, ampicillin resistance was documented in 85% of antibiotic-exposed infants and in 63% of nonexposed infants ( P = .19). Corresponding rates for first-generation cephalosporin resistance in urinary tract infection were 75% and 23.5% ( P = .04). Conclusion. IPA is associated with a trend toward increased antibiotic resistance in late-onset SBIs. This should be taken into consideration in the selection of empirical therapy for febrile infants.Keywords
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