Anti-inflammatory and analgesic properties of the ethanolic extract of Cnidoscolus aconitifolius in rats and mice
- 1 June 2011
- journal article
- research article
- Published by Walter de Gruyter GmbH in Journal of Basic and Clinical Physiology and Pharmacology
- Vol. 22 (1-2), 37-41
- https://doi.org/10.1515/jbcpp.2011.010
Abstract
Ethanolic leaf extract of Cnidoscolus aconitifolius was evaluated for analgesic and anti-inflammatory activities. The analgesic activity of the extract was assayed by the formalin-induced paw licking test, acetic acid-induced abdominal writhing and hot plate test, whereas its anti-inflammatory activity was determined by its effects on carrageenan-induced paw edema. The extract of C. aconitifolius prolonged the reaction time of mice to pain in a dose-dependent manner. The optimal analgesic effect of the extract was obtained when the extract was administered 90 min before pain stimulation in the hot plate test. The extract of C. aconitifolius (100 or 200 mg/kg b.w.) inhibited acetic acid-induced irritation of paws of rats comparably with that of indomethacin (10 mg/kg b.w.) and had significantly lower mean number of lickings of paws than the control rats (p<0.05). Carrageenan-induced edema was markedly inhibited (p<0.05) by the extracts (100 and 200 mg/kg b.w.) when compared with control rats. Inhibition of writhing movement in rats administered with the extract was lower (p<0.05) than rats administered with indomethacin but its effect was dose-dependent. Our investigations show that C. aconitifolius possesses significant anti-inflammatory and analgesic activities that should be explored.Keywords
This publication has 27 references indexed in Scilit:
- Phytochemical Investigation and Proximate Analysis on the Leaves of Cnidoscolus aconitifoliusJournal of Medicinal Food, 2011
- Methanolic Extract of Cnidoscolus aconitifolius Attenuates Renal Dysfunction Induced by Chronic Ethanol Administration in Wistar RatsAlcohol and Alcoholism, 2010
- Antinociceptive action of the extract and the flavonoid quercitrin isolated from Bauhinia microstachya leavesJournal of Pharmacy and Pharmacology, 2005
- Effect of Some Post-Harvest Treatments on the Nutritional Properties of Cnidoscolus acontifolus LeafPakistan Journal of Nutrition, 2005
- Effect of age of regrowth on chemical composition of chaya (Cnidoscolus aconitifolius) leavesJournal of the Science of Food and Agriculture, 2003
- Tumour necrosis factor- α mediates carrageenin-induced knee-joint incapacitation and also triggers overt nociception in previously inflamed rat knee-jointsPain, 1999
- Anti-Inflammatory Activity of Unusual Lupane Saponins fromBupleurum fruticescensPlanta Medica, 1998
- The Biology of Cachectin/TNF -- A Primary Mediator of the Host ResponseAnnual Review of Immunology, 1989
- The formalin test in mice: dissociation between inflammatory and non-inflammatory painPain, 1987
- The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and catsPain, 1977