Geographic distribution and characteristics of genotype A hepatitis B virus infection in acute and chronic hepatitis B patients in Japan
- 25 June 2015
- journal article
- research article
- Published by Wiley in Journal of Gastroenterology and Hepatology
- Vol. 31 (1), 180-189
- https://doi.org/10.1111/jgh.13030
Abstract
Background and Aims The prevalence of sexually transmitted acute infections of the genotype A hepatitis B virus (HBV) has been increasing in Japan. Genotype A HBV is associated with an increased risk of HBV progression to chronic infection after acute hepatitis B (AHB) in adults. A nationwide survey was conducted to evaluate the geographic distribution, clinical, and virologic characteristics of genotype A AHB and chronic hepatitis B (CHB) in Japan. Methods Five hundred seventy AHB patients were recruited between 2005 and 2010, and 3682 CHB patients were recruited between 2010 and 2011. HBV genotypes were determined for 552 and 3619 AHB and CHB patients, respectively. Clinical characteristics were compared among different genotypes in AHB and CHB patients. Genomic characteristics of HBV genotype A were examined by molecular evolutionary analysis. Results Hepatitis B virus genotype A was the predominant genotype for AHB between 2005 and 2010. Phylogenetic analysis showed that all strains in the AHB patients with genotype A were classified into subtype Ae. Among CHB patients, the occurrence of genotype A was 4.1%, and genotype A was spreading in young adults. In genotype A CHB patients, early stage liver diseases were predominant, although liver diseases progressed to cirrhosis or hepatocellular carcinoma in some patients. Conclusions The distribution of HBV genotypes is quite different between AHB and CHB in Japanese patients. Genotype A infection is spreading in young adults of Japanese CHB patients. Sequences derived from Japanese AHB patients were identical to or closely resembled the sequences derived from other Japanese AHB patients.Keywords
Funding Information
- Japanese Ministry of Health, Labor and Welfare (H21-003)
- National Center for Global Health and Medicine (22790679)
- Japanese Ministry of Education, Culture, Sports, Science and Technology
This publication has 35 references indexed in Scilit:
- Outbreak of Infections by Hepatitis B Virus Genotype A and Transmission of Genetic Drug Resistance in Patients Coinfected with HIV-1 in JapanJournal of Clinical Microbiology, 2011
- Geographical and genetic diversity of the human hepatitis B virusHepatology Research, 2010
- Distribution of Hepatitis B Virus Genotypes among Patients with Chronic Infection in Japan Shifting toward an Increase of Genotype AJournal of Clinical Microbiology, 2009
- Characterization of Genotype-Specific Carboxyl-Terminal Cleavage Sites of Hepatitis B Virus e Antigen Precursor and Identification of Furin as the Candidate EnzymeJournal of Virology, 2009
- Spatial and chronological differences in hepatitis B virus genotypes from patients with acute hepatitis B in JapanHepatology Research, 2006
- Outbreak of hepatitis B in a nursing home associated with capillary blood samplingEpidemiology and Infection, 2006
- T1653 Mutation in the Box a Increases the Riskof Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Virus Genotype C InfectionClinical Infectious Diseases, 2006
- Genetic Diversity of Hepatitis B Virus Strains Derived Worldwide: Genotypes, Subgenotypes, and HBsAg SubtypesIntervirology, 2004
- Hepatitis B virus genotypes: Do they play a role in the outcome of HBV infection?Hepatology, 2004
- Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotideJournal of Molecular Evolution, 1982