Repeatability of Perimacular Ganglion Cell Complex Analysis with Spectral-Domain Optical Coherence Tomography
Open Access
- 1 July 2015
- journal article
- research article
- Published by Hindawi Limited in Journal of Ophthalmology
- Vol. 2015, 1-5
- https://doi.org/10.1155/2015/605940
Abstract
Purpose. To assess the repeatability of spectral-domain optical coherence tomography to measure macular and perimacular ganglion cell complex thicknesses and compare retinal ganglion cell parameters between algorithms.Methods. Ninety-two nonglaucomatous eyes from 92 participants underwent macular and perimacular ganglion cell complex thickness measurement using OCT-HS100 Glaucoma 3D algorithm and these measurements were repeated for 34 subjects. All subjects also had macular ganglion cell-inner plexiform layer thickness measured by Cirrus HD-OCT Ganglion Cell Analysis algorithm. Intraclass correlation coefficient and Pearson’s correlation analyses were performed.Results. Subfields of both macular and perimacular ganglion cell complex thicknesses had high intraclass correlation coefficient values between 0.979 (95% confidence interval [CI]: 0.958–0.989) and 0.981 (95% CI: 0.963, 0.991) and between 0.70 (95% CI: 0.481–0.838) and 0.987 (95% CI: 0.956–0.989), respectively. The overall average ganglion cell complex and macular average ganglion cell-inner plexiform layer thicknesses were strongly correlated. Conclusions. The assessment of macular and perimacular retinal ganglion cell parameters by OCT-HS100 Glaucoma 3D algorithm is highly repeatable, and strongly correlates to retinal ganglion cell parameters assessed by Ganglion Cell Analysis algorithm. A comprehensive evaluation of retinal ganglion cells may be possible with OCT-HS100.
Keywords
This publication has 22 references indexed in Scilit:
- Relationship Between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients With Open-Angle GlaucomaInvestigative Opthalmology & Visual Science, 2014
- Width of abnormal ganglion cell complex area determined using optical coherence tomography to predict glaucomaJapanese Journal of Ophthalmology, 2013
- Determinants of Ganglion Cell–Inner Plexiform Layer Thickness Measured by High-Definition Optical Coherence TomographyInvestigative Opthalmology & Visual Science, 2012
- Early Neurodegeneration in the Retina of Type 2 Diabetic PatientsInvestigative Opthalmology & Visual Science, 2012
- Spectral-domain optical coherence tomography for early glaucoma assessment: analysis of macular ganglion cell complex versus peripapillary retinal nerve fiber layerCanadian Journal of Ophthalmology, 2011
- Macular Ganglion Cell–Inner Plexiform Layer: Automated Detection and Thickness Reproducibility with Spectral Domain–Optical Coherence Tomography in GlaucomaInvestigative Opthalmology & Visual Science, 2011
- Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopiaBritish Journal of Ophthalmology, 2010
- Decreased Retinal Ganglion Cell Layer Thickness in Patients with Type 1 DiabetesInvestigative Opthalmology & Visual Science, 2010
- Detection of Macular Ganglion Cell Loss in Glaucoma by Fourier-Domain Optical Coherence TomographyOphthalmology, 2009
- Evaluating the optic disc and retinal nerve fiber layer in glaucoma. I: Clinical examination and photographic methods.Seminars in Ophthalmology, 2000