Pan-cancer analysis of intratumor heterogeneity as a prognostic determinant of survival
Open Access
- 28 January 2016
- journal article
- Published by Impact Journals, LLC in Oncotarget
- Vol. 7 (9), 10051-10063
- https://doi.org/10.18632/oncotarget.7067
Abstract
// <![CDATA[ $('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); // ]]> Luc G.T. Morris1,2,*, Nadeem Riaz1,3*, Alexis Desrichard1, Yasin Şenbabaoğlu4, A. Ari Hakimi2, Vladimir Makarov1, Jorge S. Reis-Filho1,5 and Timothy A. Chan1,3 1 Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA 2 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA 3 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA 4 Computational Biology Center, Memorial Sloan Kettering Cancer Center, New York, NY, USA 5 Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA * These authors have contributed equally to this work Correspondence to: Luc G.T. Morris, email: // <![CDATA[ mail("morrisl","mskcc",1,"") // ]]> Timothy A. Chan, email: // <![CDATA[ mail("chant","mskcc",1,"") // ]]> Keywords: heterogeneity, evolution, survival, cancer, immune surveillance Received: January 14, 2016 Accepted: January 21, 2016 Published: January 28, 2016Keywords
This publication has 42 references indexed in Scilit:
- Emerging landscape of oncogenic signatures across human cancersNature Genetics, 2013
- Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancerNature, 2012
- The Life History of 21 Breast CancersCell, 2012
- Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion SequencingThe New England Journal of Medicine, 2012
- Single-Cell Exome Sequencing Reveals Single-Nucleotide Mutation Characteristics of a Kidney TumorCell, 2012
- Clonal evolution in cancerNature, 2012
- Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencingNature, 2012
- Distant metastasis occurs late during the genetic evolution of pancreatic cancerNature, 2010
- Genome remodelling in a basal-like breast cancer metastasis and xenograftNature, 2010
- Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLCCancer Cell, 2010