Oestrogens and spermatogenesis
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Open Access
- 27 May 2010
- journal article
- review article
- Published by The Royal Society in Philosophical Transactions B
- Vol. 365 (1546), 1517-1535
- https://doi.org/10.1098/rstb.2009.0235
Abstract
The role of oestrogens in male reproductive tract physiology has for a long time been a subject of debate. The testis produces significant amounts of oestrogenic hormones, via aromatase, and oestrogen receptors (ERs)α (ESR1) and ERβ (ESR2) are selectively expressed in cells of the testis as well as the epididymal epithelium, depending upon species. This review summarizes the current knowledge concerning the presence and activity of aromatase and ERs in testis and sperm and the potential roles that oestrogens may have in mammalian spermatogenesis. Data show that physiology of the male gonad is in part under the control of a balance of androgens and oestrogens, with aromatase serving as a modulator.Keywords
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