Renal Hypertension in Rabbits Immunized with Angiotensin - II

Abstract

In 9 rabbits immunized with angiotensin II and in 3 control rabbits, renal hypertension was produced by wrapping one kidney in silk saturated with turpentine, and removing the other kidney 4 weeks later; both groups developed hypertension within a few days. Intravenous injections of renin and angiotensin had no effect in the immunized rabbits, but raised blood pressure in hypertensive controls. Serum from immunized rabbits was highly potent in binding of radioactively-labelled angiotensin, and could neutralize the pressor effect of large amounts of angiotensin. We conclude that renal hypertension induced in the immunized rabbits is not dependent on the acute pressor effect of angiotensin and renin.