Hepatotoxic Cyanobacteria: A Review of the Biological Importance of Microcystins in Freshwater Environments
- 14 December 2005
- journal article
- review article
- Published by Taylor & Francis Ltd in Journal of Toxicology and Environmental Health, Part B
- Vol. 8 (1), 1-37
- https://doi.org/10.1080/10937400590889412
Abstract
Cyanobacteria possess many adaptations to develop population maxima or “blooms” in lakes and reservoirs. A potential consequence of freshwater blooms of many cyanobacterial species is the production of potent toxins, including the cyclic hepatotoxins, microcystins (MCs). Approximately 70 MC variants have been isolated. Their toxicity to humans and other animals is well studied, because of public health concerns. This review focuses instead on the production and degradation of MCs in freshwater environments and their effects on aquatic organisms. Genetic research has revealed the existence of MC-related genes, yet the expression of these genes seems to be regulated by complex mechanisms and is influenced by environmental factors. In natural water bodies, the species composition of cyanobacterial communities and the ratio of toxic to nontoxic species and strains are largely responsible for total toxin production. Cyanobacteria play vital roles in aquatic food webs, yet production, accumulation, and toxicity patterns of MCs within aquatic food webs remain obscure.Keywords
This publication has 313 references indexed in Scilit:
- Mechanism and prediction for contamination of freshwater bivalves (Unionidae) with the cyanobacterial toxin microcystin in hypereutrophic Lake Suwa, JapanEnvironmental Toxicology and Water Quality, 2002
- Deoxycylindrospermopsin, an analog of cylindrospermopsin fromCylindrospermopsis raciborskiiEnvironmental Toxicology and Water Quality, 1999
- Seasonal variations in microcystin contents of danish cyanobacteriaNatural Toxins, 1997
- Toxicity of microcystin-LR, isolated from Microcystis aeruginosa, against various insect speciesToxicon, 1995
- Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteinsChemico-Biological Interactions, 1992
- In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblastsBiochemical and Biophysical Research Communications, 1990
- Toxic cyanobacteria (blue-green algae) in Finnish fresh and coastal watersHydrobiologia, 1990
- Cell to cell recognition between the ciliatePseudomicrothorax dubius and its food organisms: the role of surface chargesProtoplasma, 1988
- Effects of the peptide toxin from Microcystis aeruginosa on intracellular calcium, pH and membrane integrity in mammalian cellsChemico-Biological Interactions, 1987
- Feeding behaviour of silver carp Hypophthalmichthys molitrix Val. and its impact on the food web in Lake Kinneret, IsraelHydrobiologia, 1985