Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties
- 15 April 2008
- journal article
- Published by Elsevier BV in Bioorganic & Medicinal Chemistry
- Vol. 16 (8), 4252-4261
- https://doi.org/10.1016/j.bmc.2008.02.083
Abstract
No abstract availableKeywords
This publication has 31 references indexed in Scilit:
- Novel tricyclic quinazolinimines and related tetracyclic nitrogen bridgehead compounds as cholinesterase inhibitors with selectivity towards butyrylcholinesteraseBioorganic & Medicinal Chemistry, 2006
- Novel Tacrine−Melatonin Hybrids as Dual-Acting Drugs for Alzheimer Disease, with Improved Acetylcholinesterase Inhibitory and Antioxidant PropertiesJournal of Medicinal Chemistry, 2005
- Novel inhibitors of acetyl- and butyrylcholinesterase derived from the alkaloids dehydroevodiamine and rutaecarpineEuropean Journal of Medicinal Chemistry, 2005
- Oxidative stress mechanisms and potential therapeutics in Alzheimer diseaseJournal of Neural Transmission, 2004
- Vitamin E in Neurodegenerative Disorders: Alzheimer's DiseaseAnnals of the New York Academy of Sciences, 2004
- Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's diseaseThe FASEB Journal, 2003
- Oxidative stress in brain aging: Implications for therapeutics of neurodegenerative diseasesNeurobiology of Aging, 2002
- Inhibition of acetyl- and butyryl-cholinesterase in the cerebrospinal fluid of patients with Alzheimer's disease by rivastigmine: correlation with cognitive benefitJournal of Neural Transmission, 2002
- Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the EnzymeNeuron, 1996
- Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia.BMJ, 1978