EULAR Sjögren's syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjögren's syndrome
- 28 June 2009
- journal article
- review article
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 69 (6), 1103-1109
- https://doi.org/10.1136/ard.2009.110619
Abstract
Objective To develop a disease activity index for patients with primary Sjögren's syndrome (SS): the European League Against Rheumatism (EULAR) Sjögren's syndrome disease activity index (ESSDAI). Methods Thirty-nine SS experts participated in an international collaboration, promoted by EULAR, to develop the ESSDAI. Experts identified 12 organ-specific ‘domains’ contributing to disease activity. For each domain, features of disease activity were classified in three or four levels according to their severity. Data abstracted from 96 patients with systemic complications of primary SS were used to generate 702 realistic vignettes for which all possible systemic complications were represented. Using the 0–10 physician global assessment (PhGA) scale, each expert scored the disease activity of five patient profiles and 20 realistic vignettes. Multiple regression modelling, with PhGA used as the dependent variable, was used to estimate the weight of each domain. Results All 12 domains were significantly associated with disease activity in the multivariate model, domain weights ranged from 1 to 6. The ESSDAI scores varied from 2 to 47 and were significantly correlated with PhGA for both real patient profiles and realistic vignettes (r=0.61 and r=0.58, respectively, pConclusions The ESSDAI is a clinical index designed to measure disease activity in patients with primary SS. Once validated, such a standardised evaluation of primary SS should facilitate clinical research and be helpful as an outcome measure in clinical trials.Keywords
This publication has 32 references indexed in Scilit:
- Comparison of disease activity measures for anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitisAnnals Of The Rheumatic Diseases, 2008
- Assessment of the item selection and weighting in the Birmingham Vasculitis Activity Score for Wegener's GranulomatosisArthritis Care & Research, 2008
- Tolerance and efficacy of rituximab and changes in serum B cell biomarkers in patients with systemic complications of primary Sjogren's syndromeAnnals Of The Rheumatic Diseases, 2007
- Correlation of serum B lymphocyte stimulator and 2 microglobulin with autoantibody secretion and systemic involvement in primary Sjogren's syndromeAnnals Of The Rheumatic Diseases, 2005
- Derivation of the sledai. A disease activity index for lupus patientsArthritis & Rheumatism, 1992
- High Breakdown-Point and High Efficiency Robust Estimates for RegressionThe Annals of Statistics, 1987
- Cyclosporin A (CyA) in primary Sjogren's syndrome: a double blind study.Annals Of The Rheumatic Diseases, 1986
- Least Median of Squares RegressionJournal of the American Statistical Association, 1984
- Weighted kappa: Nominal scale agreement provision for scaled disagreement or partial credit.Psychological Bulletin, 1968
- A Coefficient of Agreement for Nominal ScalesEducational and Psychological Measurement, 1960