Detection of A B acute lymphoblastic leukaemia blast-specific mutation in HLA-B*39:01
- 11 April 2011
- journal article
- case report
- Published by Wiley in International Journal of Immunogenetics
- Vol. 38 (4), 285-286
- https://doi.org/10.1111/j.1744-313x.2011.01007.x
Abstract
Human leucocyte antigen (HLA) modifications observed in blast cells in haematologic malignancies can play an important role in disease progression and its therapy. Here we describe an insertion/deletion mutation in the second exon of HLA-B*39:01 that occurred in the blast cells of a patient with B-ALL. This mutation was not present in the nonleukemic cells, in which HLA-B*39:01 was normally expressed.Keywords
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