The Impact of Osteopontin Gene Variations on Multiple Sclerosis Development and Progression
Open Access
- 1 January 2012
- journal article
- research article
- Published by Hindawi Limited in Journal of Immunology Research
- Vol. 2012, 1-6
- https://doi.org/10.1155/2012/212893
Abstract
Osteopontin is a proinflammatory molecule, modulating TH1 and TH17 responses. Several reports suggest its involvement in multiple sclerosis (MS) pathogenesis. We previously reported that OPN gene variations at the 3′ end are a predisposing factor for MS development and evolution. In this paper, we extended our analysis to a gene variation at the 5′ end on thesingle nucleotide polymorphism (SNP) and replicated our previous findings at the 3′ end on theSNP. We found that onlySNP displayed a statistically significant association with MS development, but bothandhad an influence on MS progression, since patients homozygous for both +1239A and −156GG alleles displayed slower progression of disability and slower switch to secondary progression than those carrying +1239C and/or −156G and those homozygous for +1239A only. Moreover, patients homozygous for +1239A also displayed a significantly lower relapse rate than those carrying +1239C, which is in line with the established role of OPN in MS relapses.
Keywords
Funding Information
- Fondazione Cariplo (502/92)
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